Subheading: The synthesis provider combines deep technical mastery, scalable production, and rigorous QC to serve advanced research and diagnostic applications.
For Immediate Release – The demand for high-quality, complex synthetic nucleic acids is surging in fields like molecular diagnostics, therapeutic development, and advanced research. Meeting this demand requires not just synthesis capability, but deep expertise in chemistry, modifications, and scale. BioPohe, with over 30 years of focused experience, has established itself as a trusted partner for custom oligonucleotide and gene synthesis, supporting clients worldwide.
A Comprehensive Portfolio: From Nano-Scale Modifications to Full Genes
BioPohe’s service breadth addresses a wide spectrum of needs. Its oligonucleotide synthesis capabilities encompass DNA Oligos (10-100 bases), single-stranded RNA, siRNA, miRNA, and ASOs. A key differentiator is its extensive library of over 100 chemical modifications, including fluorescent dyes, quenchers, affinity tags (e.g., biotin), backbone modifications (e.g., phosphorothioate), and nucleotides with altered sugar chemistry (2’-OMe, 2’-F). For larger constructs, BioPohe offers a complete gene synthesis workflow, from sequence design and codon optimization to synthesis, cloning, and 100% validation by Sanger sequencing, with support for custom vectors.
The Foundation of Trust: Stringent, Multi-Layered Quality Control
Product consistency and purity are paramount. BioPohe manufactures in a 500 m² ISO Class 8 (Class 100,000) cleanroom utilizing state-of-the-art automated synthesis platforms. Quality is verified through orthogonal methods: Mass Spectrometry (MS) for sequence identity, HPLC for purity assessment, and PAGE for length verification. This rigorous process is governed by a certified ISO 9001 and ISO 13485 quality management system, ensuring full traceability from raw materials to final shipment.
Scalable for Every Stage: From R&D Screens to Industrial Supply
BioPohe is equipped to support projects at any scale. For early-stage research, it offers small-scale synthesis (from 2 OD) with options for next-day delivery. When projects transition to development and production, the company’s platform can seamlessly scale to single-batch synthesis runs as large as 25,000 OD with minimal batch-to-batch variation, providing a reliable supply chain for diagnostic and therapeutic applications.
About BioPohe
A subsidiary of Shanghai BioScience Co., Ltd., BioPohe is dedicated to the synthesis of high-purity nucleic acids. Leveraging decades of expertise in nucleic acid chemistry and a modern, certified production facility, BioPohe delivers custom oligonucleotides and genes that meet the exacting standards of global research, diagnostic, and pharmaceutical partners.